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MYP_046710
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Basic Information
Lantibiotic nisin-Z
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
34 amino acids
C141H245N41O46S7
Standard
Sequence
ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK
Physicochemical Analysis
3475.16 Da
8.78
2.79
2.46
0.0822
0.41
0.29
0.16
17.08
71.76
0.0000
0.00
250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1389.82
-20.14
54.0
57.0
115.0
235.0
2.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0324447 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]; Bacteria [Bacterium]
1358; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID1733929 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1733929/
RECORD: Rec_0374589 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis subsp. lactis [Bacterium]
type A lantibiotic family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-Thr: 2,3-didehydrobutyrine; 5-Ser: 2,3-didehydroalanine (Ser); 33-Ser: 2,3-didehydroalanine (Ser)
Bio-Activity Profile
Antimicrobial type A lantibiotic family Antibacterial Host defense
PaperPDB 1WCO structural record; NMR; chain N; residues 1-34
RECORD: Rec_0382298 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
1358
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
A variant of nisin A. It differs from Nisin A only by one aa at residue at position 27: N for nisin Z and H for Nisin. Chemical modification: There are two di-dehydroalanines (Dha), S5, S33; one di-dehydrobutyrine (Dhb), T2; one lanthionine, S3-C7; and four methyllanthionines, T8-C11, T13-C19, T23-C26, and T25-C28 (provided by T. Stein)
Bio-Activity Profile
Antimicrobial Antiviral Anticancer
Lactococcus lactis MG1363
0.02 μg/mL
MIC
PaperIdentification and characterization of the lantibiotic nisin Z, a natural nisin variant.
RECORD: Rec_0385906 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis subsp. lactis [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
There are two dehydroalanines (S5; S33), one dehydrobutyrine (T2), which form one lanthionine (S3-C7) and four β-methyllanthionines (T8-C11; T13-C19; T23-C26; T25-C28)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
clostridium
PaperPubMed PMID: 1935953 | PubMed PMID: 7626780 | PubMed PMID: 15361862 PMID1935953;7626780;15361862 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1935953/
RECORD: Rec_0393559 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Anti-Gram-positive
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
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