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MYP_046710
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Basic Information
Lantibiotic nisin-Z
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
34 amino acids
C141H245N41O46S7
Standard
Sequence
ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK
Physicochemical Analysis
3475.16 Da
8.78
2.79
2.46
0.0822
0.41
0.29
0.16
17.08
71.76
0.0000
0.00
250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1389.82
-20.14
54.0
57.0
115.0
235.0
2.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0167301 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0183900 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis
9.17 μg/mL
MIC
PMID28461263 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28461263/
RECORD: Rec_0194509 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
16.67 μg/mL
MIC
PMID28461263 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28461263/
RECORD: Rec_0225367 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
1358
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
A variant of nisin A. It differs from Nisin A only by one aa at residue at position 27: N for nisin Z and H for Nisin. Chemical modification: There are two di-dehydroalanines (Dha), S5, S33; one di-dehydrobutyrine (Dhb), T2; one lanthionine, S3-C7; and four methyllanthionines, T8-C11, T13-C19, T23-C26, and T25-C28 (provided by T. Stein)
Bio-Activity Profile
Antimicrobial Antiviral Anticancer
Listeria monocytogenes LMG10470 or TT82E or LK132
1.5-12.5 μg/mL
MIC
PaperIdentification and characterization of the lantibiotic nisin Z, a natural nisin variant.
RECORD: Rec_0271587 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis subsp. lactis [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
There are two dehydroalanines (S5; S33), one dehydrobutyrine (T2), which form one lanthionine (S3-C7) and four β-methyllanthionines (T8-C11; T13-C19; T23-C26; T25-C28)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Leuconostoc
PaperPubMed PMID: 1935953 | PubMed PMID: 7626780 | PubMed PMID: 15361862 PMID1935953;7626780;15361862 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1935953/
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