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MYP_046710
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Basic Information
Lantibiotic nisin-Z
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
34 amino acids
C141H245N41O46S7
Standard
Sequence
ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK
Physicochemical Analysis
3475.16 Da
8.78
2.79
2.46
0.0822
0.41
0.29
0.16
17.08
71.76
0.0000
0.00
250.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1389.82
-20.14
54.0
57.0
115.0
235.0
2.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0047273 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis subsp. lactis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
PMID1935953 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1935953/
RECORD: Rec_0049407 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
1358
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
A variant of nisin A. It differs from Nisin A only by one aa at residue at position 27: N for nisin Z and H for Nisin. Chemical modification: There are two di-dehydroalanines (Dha), S5, S33; one di-dehydrobutyrine (Dhb), T2; one lanthionine, S3-C7; and four methyllanthionines, T8-C11, T13-C19, T23-C26, and T25-C28 (provided by T. Stein)
Bio-Activity Profile
Antimicrobial Antiviral Anticancer
Staphylococcus aureus LMG10147 or LMG15975 or MRSA
6.25 μg/mL
MIC
PaperIdentification and characterization of the lantibiotic nisin Z, a natural nisin variant.
RECORD: Rec_0069278 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis subsp. lactis [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
There are two dehydroalanines (S5; S33), one dehydrobutyrine (T2), which form one lanthionine (S3-C7) and four β-methyllanthionines (T8-C11; T13-C19; T23-C26; T25-C28)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Lactococcus
PaperPubMed PMID: 1935953 | PubMed PMID: 7626780 | PubMed PMID: 15361862 PMID1935953;7626780;15361862 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1935953/
RECORD: Rec_0085026 VERIFIED: YES
Provenance & Taxonomy
Lactococcus lactis [Bacterium]
Bacteriocin
1358
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
A variant of nisin A. It differs from Nisin A only by one aa at residue at position 27: N for nisin Z and H for Nisin. Chemical modification: There are two di-dehydroalanines (Dha), S5, S33; one di-dehydrobutyrine (Dhb), T2; one lanthionine, S3-C7; and four methyllanthionines, T8-C11, T13-C19, T23-C26, and T25-C28 (provided by T. Stein)
Bio-Activity Profile
Antimicrobial Antiviral Anticancer
Enterococcus faecium LMG11423 or LMG16003 or LMG16216
3.13 μg/mL
MIC
PaperIdentification and characterization of the lantibiotic nisin Z, a natural nisin variant.
RECORD: Rec_0123334 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
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