Peptide Database

Peptide Name[D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P

Function Ontology

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide growth factor antagonist

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC79H108N18O13

DescriptionStandard

        RPKPFQWFWLL
    

Molecular Weight1517.82 Da

Isoelectric Point (pI)11.00

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.1599

GRAVY Index-0.34

Hydrophobic Moment 0.07

Boman Index0.13

Instability Index48.47

Aliphatic Index 70.91

Aromaticity 0.3636

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 499.33

LogP 1.94

H-bond Donors 17.0

H-bond Acceptors 15.0

Rotatable Bonds 42.0

Heavy Atoms 110.0

Ring Count 8.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0085584 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilySubstance P

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermNone

C-TermAmidation

Other ModsD-residue notation at positions 1, 5, 7, 9; Mixed L/D stereochemistry with D-annotated positions 1, 5, 7, 9

Bio-Activity Profile

Function

Neuropeptide growth factor antagonist

MethodRP-HPLC

Half-LifeIntraperitonial injection to Nu/Nu mice, in vivo; 2754 s