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MYP_046650
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Basic Information
Dermaseptin DRS-DU-1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
28 amino acids
C129H219N37O37S
Standard
Sequence
ALWKSLLKNVGKAAGKAALNAVTDMVNQ
Physicochemical Analysis
2912.41 Da
10.00
2.79
2.60
0.0998
0.15
0.66
0.12
0.25
108.21
0.0357
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1219.01
-12.24
41.0
41.0
100.0
204.0
2.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0123353 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Staphylococcus aureus MRSA
4 μM
MIC
PaperDiscovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells.
RECORD: Rec_0142060 VERIFIED: YES
Provenance & Taxonomy
Animalia [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID30258724 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30258724/
RECORD: Rec_0204793 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Klebsiella pneumoniae
4 μM
MIC
PaperDiscovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells.
RECORD: Rec_0211619 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa duellmani [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
Horse erythrocytes
216.6 μM
Hemolysis
PMID30258724 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30258724/
RECORD: Rec_0292459 VERIFIED: YES
Provenance & Taxonomy
Animalia [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
H157
8.43 μM
IC50
PMID30258724 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30258724/
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