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MYP_046650
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Basic Information
Dermaseptin DRS-DU-1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
28 amino acids
C129H219N37O37S
Standard
Sequence
ALWKSLLKNVGKAAGKAALNAVTDMVNQ
Physicochemical Analysis
2912.41 Da
10.00
2.79
2.60
0.0998
0.15
0.66
0.12
0.25
108.21
0.0357
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1219.01
-12.24
41.0
41.0
100.0
204.0
2.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0023279 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa duellmani [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus NCTC 10788
4 μM
MIC
PMID30258724 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30258724/
RECORD: Rec_0061170 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Escherichia coli
4 μM
MIC
PaperDiscovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells.
RECORD: Rec_0079669 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
also come toxicity to normal HMEC-1 cells
53.75 μM
HC50
PaperDiscovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells.
RECORD: Rec_0087925 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Candida albicans
4 μM
MIC
PaperDiscovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells.
RECORD: Rec_0121534 VERIFIED: YES
Provenance & Taxonomy
Animalia [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID30258724 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30258724/
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