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MYP_046640
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Basic Information
K-Dermaseptin-S1 (1-15)[W31NAL]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
16 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
KALXKTMLKKLGTMAL
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0160888 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
The 'X' at position 4 indicates Nal (3-[1-naphthyl]alanine)
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
Vero cells
50 μM
CC50
PaperPubMed PMID: 20718719 PMID20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20718719/
RECORD: Rec_0169525 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 4
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Antiparasitic Antiprotozoal Antifungal
Staphylococcus aureus Cowan 1
5.1 μM
MIC
PMID18676150;20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18676150/
RECORD: Rec_0212960 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 4
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Antiparasitic Antiprotozoal Antifungal
Pseudomonas aeruginosa
10.5 μM
MIC
PMID18676150;20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18676150/
RECORD: Rec_0245941 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 4
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Antiparasitic Antiprotozoal Antifungal
Staphylococcus aureus
21 μM
MIC
PMID18676150;20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18676150/
RECORD: Rec_0246594 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 4
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Antiparasitic Antiprotozoal Antifungal
Bacillus subtilis ATCC 9466
5.2 μM
MIC
PMID18676150;20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18676150/
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