‹ ›
MYP_046491
← PREVIOUS NEXT → BACK
Basic Information
Kalata-B8 (Plant defensin)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
31 amino acids
C134H220N38O47S6
Standard
Sequence
GSVLNCGETCLLGTCYTTGCTCNKYRVCTKD
Physicochemical Analysis
3307.80 Da
7.76
0.70
0.40
0.0227
-0.02
0.32
0.01
27.53
56.45
0.0645
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1393.11
-19.72
56.0
54.0
107.0
225.0
2.0
32.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0359119 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
60225
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Toxicity
CEM-ss cells
>3.5 μM
TC50
PaperKalata B8, a novel antiviral cicular protein, exhibits conformational flexibility in the cysteine knot motif
RECORD: Rec_0409782 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0413196 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Cyclotide
60225
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Molluscicidal Anti-HIV Cytotoxic
Pomacea canaliculata
PMID18557620;16207170 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18557620/
FIRST PREV 1 2 3 4
Showing 3 records on this page · Page 4 of 4