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MYP_046489
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Basic Information
HKU4-HR2P1
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
37 amino acids
C183H298N44O61S2
Standard
Sequence
GPNFAEISKINTTLLDLSDEMAMLLQEVVKQLNDSYI
Physicochemical Analysis
4154.71 Da
4.05
-4.23
-4.45
-0.1144
0.04
0.65
0.13
34.45
115.95
0.0541
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1714.80
-15.38
56.0
59.0
142.0
290.0
3.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0329511 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PMID30646495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30646495/
RECORD: Rec_0370332 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibition
MERS-CoV Q1020H | Huh-7 cells
2.72 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperPotent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4. | Xia S, Lan Q, Pu J, Wang C, Liu Z, Xu W, Wang Q, Liu H, Jiang S, Lu L. | Viruses. 2019 Jan 14;11(1):56. doi: 10.3390/v11010056 | DOI:10.3390/v11010056 | PMID:30646495 PMID30646495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30646495/
RECORD: Rec_0389524 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
MERS-CoV Q1020:inhibition of Pseudovirus Infection in Huh-7 cells
2.15 μM
IC50
PMID30646495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30646495/
RECORD: Rec_0408313 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Virus:MERS-CoV:inhibition of cell-cell fusion between 293T cells and Huh-7 cells
1.09 μM
IC50
PMID30646495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30646495/
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