Peptide Database

Peptide NameSLAY-screened peptide P5275

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC107H150N28O30S

DescriptionStandard

        ADVFAASGRDTWSYYIMLHH
    

Molecular Weight2340.57 Da

Isoelectric Point (pI)5.98

Net Charge (pH 7.0)-1.03

Net Charge (pH 7.4) -1.32

Charge Density (pH 7.0) -0.0515

GRAVY Index-0.07

Hydrophobic Moment 0.38

Boman Index0.17

Instability Index-3.60

Aliphatic Index 68.50

Aromaticity 0.2000

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 927.02

LogP -6.83

H-bond Donors 34.0

H-bond Acceptors 32.0

Rotatable Bonds 70.0

Heavy Atoms 166.0

Ring Count 7.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0300298 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/