Peptide Database

Peptide NameCGRP(8-37)-NH2 derivative 32

Function Ontology

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC135H223N41O38S2

DescriptionStandard

        WVTHCITLAGLLSCITSGGVVHARGKNNAL
    

Molecular Weight3092.60 Da

Isoelectric Point (pI)8.96

Net Charge (pH 7.0)1.91

Net Charge (pH 7.4) 1.58

Charge Density (pH 7.0) 0.0638

GRAVY Index0.64

Hydrophobic Moment 0.33

Boman Index0.28

Instability Index13.33

Aliphatic Index 117.00

Aromaticity 0.0333

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1255.62

LogP -13.93

H-bond Donors 47.0

H-bond Acceptors 44.0

Rotatable Bonds 99.0

Heavy Atoms 216.0

Ring Count 4.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0117663 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyCalcitonin

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermAcetylation

C-TermAmidation

Other ModsComposite modified token NalVOicTDVGOicFA

Bio-Activity Profile

Function

Neuropeptide

Activity0.00357±4e-05 μM

MethodIC50

Half-LifeHuman plasma, in vitro; 244800 s