Peptide Database

Peptide NameDefensin-6 (Defensin; alpha 6)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Antimicrobial ▸ Antifungal ▸ Fungicidal activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length100 amino acids

Chemical FormulaC470H743N135O153S8

DescriptionStandard

        MRTLTILTAVLLVALQAKAEPLQAEDEPLQAKAYEADAQEQRGANDQDFAVSFAEDASSSLRALGSTRAFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL
    

Molecular Weight10989.26 Da

Isoelectric Point (pI)5.23

Net Charge (pH 7.0)-3.37

Net Charge (pH 7.4) -3.79

Charge Density (pH 7.0) -0.0337

GRAVY Index-0.17

Hydrophobic Moment 0.57

Boman Index-0.02

Instability Index57.26

Aliphatic Index 73.40

Aromaticity 0.0800

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 6335.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4666.26

LogP -54.96

H-bond Donors 170.0

H-bond Acceptors 160.0

Rotatable Bonds 362.0

Heavy Atoms 766.0

Ring Count 12.0

Amide Bonds 107.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0314483 VERIFIED: YES

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Antibiofilm Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetB. longum (Gram-positive)

RECORD: Rec_0359289 VERIFIED: YES

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Antibiofilm Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetCandida albicans

RECORD: Rec_0382422 VERIFIED: YES

Provenance & Taxonomy

OrganismPan troglodytes [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9598

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Antifungal Antibiofilm Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetListeria monocytogenes (Gram-positive)

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