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MYP_046431
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Basic Information
I-1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C100H170N28O18
Standard
Sequence
VKRFKKFFRKLKKSVL
Physicochemical Analysis
2052.60 Da
12.00
7.73
7.51
0.4830
-0.55
0.95
-0.40
7.94
85.00
0.1875
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
799.97
-2.90
30.0
26.0
76.0
146.0
3.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0387775 VERIFIED: YES
Provenance & Taxonomy
cationic host defense peptides [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Rabbit red blood cells: modest hemolytic activity(as show in Fig.2)
PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
RECORD: Rec_0415905 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Human breast adenocarcinoma MCF-7/Taxol
31.1
IC50
PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
RECORD: Rec_0420288 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human umbilical vein endothelial cells HUVEC
50.62±6.1 μM
IC50
PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/
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