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MYP_046395
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Basic Information
Ascaphin-5
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
24 amino acids
C118H200N34O31
Standard
Sequence
GIKDWIKGAAKKLIKTVASHIANQ
Physicochemical Analysis
2591.06 Da
10.18
3.84
3.58
0.1601
-0.13
0.67
0.05
-0.01
110.00
0.0417
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1071.13
-8.90
37.0
36.0
91.0
183.0
3.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0208195 VERIFIED: YES
Provenance & Taxonomy
Ascaphus truei [Animal]
Ascaphin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Streptococcus Group B
6 μM
MIC
PMID15207717 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15207717/
RECORD: Rec_0211254 VERIFIED: YES
Provenance & Taxonomy
Ascaphus truei [Animal]
Ascaphin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis
13 μM
MIC
PMID15207717 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15207717/
RECORD: Rec_0225839 VERIFIED: YES
Provenance & Taxonomy
Ascaphus truei [Animal]
Ascaphin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
6 μM
MIC
PMID15207717 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15207717/
RECORD: Rec_0250739 VERIFIED: YES
Provenance & Taxonomy
Ascaphus truei [Animal]
Ascaphin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
50.0 μM
MIC
PaperJ.M. Conlon et al. / Biochemical and Biophysical Research Communications 320 (2004) 170-175. The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei Evidence URLhttps://www.uniprot.org/uniprotkb/P0CJ29/entry
RECORD: Rec_0319869 VERIFIED: YES
Provenance & Taxonomy
Ascaphus truei [Animal]
Ascaphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Hemolytic
Gram-negative and Gram-positive bacteria
PMID15207717 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15207717/
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