Peptide Database

Peptide NameInsulin A chain

Function Ontology

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Hormonal / Endocrine ▸ Hormone peptide

Metabolic

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length23 amino acids

Chemical FormulaC108H167N31O36S4

DescriptionStandard

        GIVDQCCNNICTFNQLQNYCNVP
    

Molecular Weight2603.93 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.28

Net Charge (pH 7.4) -1.54

Charge Density (pH 7.0) -0.0556

GRAVY Index-0.07

Hydrophobic Moment 0.48

Boman Index0.08

Instability Index50.28

Aliphatic Index 76.09

Aromaticity 0.0870

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1740.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1117.21

LogP -14.41

H-bond Donors 38.0

H-bond Acceptors 39.0

Rotatable Bonds 82.0

Heavy Atoms 179.0

Ring Count 3.0

Amide Bonds 30.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0016576 VERIFIED: YES

Provenance & Taxonomy

OrganismOctodon degus [Animal]

FamilyInsulin

Tax ID10160

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide6-11

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation

Half-LifeMammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0044842 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0390527 VERIFIED: NO

Provenance & Taxonomy

OrganismOctodon degus [Animal]

FamilyInsulin

Tax ID10160

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Metabolic