Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length442 amino acids

Chemical FormulaC2199H3413N547O647S25

DescriptionStandard

        MLLTVIAVLMLLSCTCGENPAIQVTLTNKGLQYGKHEATDWVQKNLEDVTLPDITGEIDISVLGSIDYTLTGIIKCDLPEPSVEFYPDATGFKTSMLGLSVALSGEWMTHYGIIHDGGSFDMAVFSVSVSSVVELGKYADGHLSVNSVSCDAQVGDVDMEFHGGARYSKKVREKDTEICPYVKKMIVNLDYHLQAMNVSFDVDQALTLDLSLTDFPFIDVSRLNLGFKGEFYSIKTHVDPPFEAQPFTMPEQQGYMLSMGLSEFTLNSASYGFYSAGGFQVLINNSMIPPGSPVHLNTSLMGPFIPQLPKMFPGLLMDLQVYATEVPMFSFQPDAVKVDFQVAVKAFAIQPNGTQTPLFKLNVVSNFSFLTDALEIMAKMGINFALAKVNQKLGKGFDLPRMKHAQLVNSVLKMQEGFVALFSDAEVLLTDRRFNRQRDGPV
    

Molecular Weight48666.52 Da

Isoelectric Point (pI)4.89

Net Charge (pH 7.0)-16.71

Net Charge (pH 7.4) -17.56

Charge Density (pH 7.0) -0.0378

GRAVY Index0.10

Hydrophobic Moment 0.64

Boman Index0.16

Instability Index31.83

Aliphatic Index 91.24

Aromaticity 0.0995

Extinction Coeff. Reduced 30370.00

Extinction Coeff. Oxidized 30620.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0007607 VERIFIED: NO

Provenance & Taxonomy

OrganismSeriola dumerili [Bacterium]

FamilyBPI

Tax ID41447

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence