Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2336H3681N581O675S23

DescriptionStandard

        MLHFVIVALMVLPHTCGQNPAIQVLLTNKGLQYGKHVGAEWIQDMLDHVTLPDIQGTFSTLFGTVSYTLSGITITKCDFPEPNVAYSQEYSGFKTSITGLSIALSGNWATKFGILHESGSFDMAIFGVDVTSVVKLERKADGHLSVSSIICDGEVQDVDIRLYGGFSWIFQPFVHYIKGHIIEEIRKNICPAVQTSIEELETHLQAMNVSFDVNQVLSLELPLTGSPVVSPSNLTLGLKGEFYSIQTHAEPPFKSKPFMMPNIPGYMLSAGVSEFTLNSAAYGYFTAGKLQILITEKMVPKFSPIHLNTSSMGPYIPQLPKLFPGLPMTLQVYATEAPTVSLQSDVVNLTIQAAVKASAVESNGSSIPLFGLNVVVMLSGKMWIADGKVKGSVMLNNFTLTLASTQVGPFKTNSLENMCKKGIELFGVPQVNKKLAEGVMLPRMKHIQPVNSILTVEKGFISISSDAQVLDML
    

Molecular Weight51442.20 Da

Isoelectric Point (pI)6.06

Net Charge (pH 7.0)-5.46

Net Charge (pH 7.4) -6.46

Charge Density (pH 7.0) -0.0116

GRAVY Index0.22

Hydrophobic Moment 0.60

Boman Index0.21

Instability Index37.92

Aliphatic Index 99.47

Aromaticity 0.0846

Extinction Coeff. Reduced 39880.00

Extinction Coeff. Oxidized 40130.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0094822 VERIFIED: NO

Provenance & Taxonomy

OrganismOryzias latipes [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence