Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length151 amino acids

Chemical FormulaC750H1212N188O214S3

DescriptionStandard

        KKLYPNMAMKLKVSPSSVPSLSISPETLSLTPSVDIQAFAILPDSSLAPLFVIEATSPVSAKIDVNSTRIFGNLKLGRLKFSLKHSDVGIFSVQLLESLINVLTASILIPQMNARLAEGFPLPLLDHLELSNPVLQAHQDFLVFASDVRYG
    

Molecular Weight16382.97 Da

Isoelectric Point (pI)7.03

Net Charge (pH 7.0)0.03

Net Charge (pH 7.4) -0.35

Charge Density (pH 7.0) 0.0002

GRAVY Index0.37

Hydrophobic Moment 0.55

Boman Index0.20

Instability Index38.73

Aliphatic Index 120.73

Aromaticity 0.0662

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6332.44

LogP -54.89

H-bond Donors 213.0

H-bond Acceptors 220.0

Rotatable Bonds 535.0

Heavy Atoms 1155.0

Ring Count 25.0

Amide Bonds 161.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0284255 VERIFIED: NO

Provenance & Taxonomy

OrganismMicrurus paraensis [Bacterium]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence