Peptide Database

Peptide NameDermaseptin-B4 (DRS-B4) (Dermaseptin BIV)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length76 amino acids

Chemical FormulaC379H620N100O123S3

DescriptionStandard

        MAFLKKSLFLVLFLGLVSLSICEEEKRENKDEIEQEDDEQSEEKRALWKDILKNVGKAAGKAVLNTVTDMVNQGEQ
    

Molecular Weight8641.77 Da

Isoelectric Point (pI)4.69

Net Charge (pH 7.0)-5.48

Net Charge (pH 7.4) -5.75

Charge Density (pH 7.0) -0.0721

GRAVY Index-0.46

Hydrophobic Moment 0.73

Boman Index-0.08

Instability Index61.20

Aliphatic Index 96.18

Aromaticity 0.0526

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3682.49

LogP -33.33

H-bond Donors 124.0

H-bond Acceptors 121.0

Rotatable Bonds 311.0

Heavy Atoms 605.0

Ring Count 5.0

Amide Bonds 83.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0026470 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa bicolor [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetGram Negative Bacteria and Gram Positive Bacteria