Peptide Database

Peptide NameAurein-2.3 (Frogs, amphibians, animals)

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC76H130N18O20

DescriptionStandard

        GLFDIVKKVVGAIGSL
    

Molecular Weight1615.95 Da

Isoelectric Point (pI)8.59

Net Charge (pH 7.0)0.76

Net Charge (pH 7.4) 0.55

Charge Density (pH 7.0) 0.0474

GRAVY Index1.28

Hydrophobic Moment 0.59

Boman Index0.46

Instability Index-5.94

Aliphatic Index 158.12

Aromaticity 0.0625

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 609.39

LogP -3.30

H-bond Donors 21.0

H-bond Acceptors 21.0

Rotatable Bonds 55.0

Heavy Atoms 114.0

Ring Count 1.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0356970 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer

RECORD: Rec_0370780 VERIFIED: YES

Provenance & Taxonomy

OrganismLitoria aurea [Animal]

FamilyAurein

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anticancer

TargetLeuconostoc lactis

Activity25 μg/mL

MethodMIC

PaperPubMed PMID: 10951191 | Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID10951191;15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10951191/

RECORD: Rec_0377432 VERIFIED: YES

Provenance & Taxonomy

OrganismLitoria aurea [Animal]

FamilyAurein

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anticancer

TargetListeria innocua

Activity100 μg/mL

MethodMIC

PaperPubMed PMID: 10951191 | Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID10951191;15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10951191/

RECORD: Rec_0379441 VERIFIED: YES

Provenance & Taxonomy

OrganismRanoidea raniformis [Animal]

Tax ID116057

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anticancer

TargetStaphylococcus aureus

Activity100 μg/mL

MethodMIC

RECORD: Rec_0385621 VERIFIED: NO

Provenance & Taxonomy

OrganismLitoria aurea [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial

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