Peptide Database

Peptide NameSLAY-screened peptide P2126

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC111H158N32O28S

DescriptionStandard

        IHSRPLSRFHVYTSYCHYGP
    

Molecular Weight2420.70 Da

Isoelectric Point (pI)9.20

Net Charge (pH 7.0)2.01

Net Charge (pH 7.4) 1.64

Charge Density (pH 7.0) 0.1004

GRAVY Index-0.57

Hydrophobic Moment 0.48

Boman Index-0.02

Instability Index70.57

Aliphatic Index 53.50

Aromaticity 0.2000

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 950.09

LogP -8.20

H-bond Donors 36.0

H-bond Acceptors 34.0

Rotatable Bonds 69.0

Heavy Atoms 172.0

Ring Count 9.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0035539 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/