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MYP_045519
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Basic Information
R12-alexa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Standard
10 amino acids
C60H122N40O11
Standard
Sequence
RRRRRRRRRR
Physicochemical Analysis
1579.87 Da
12.00
9.76
9.56
0.9760
-4.50
0.21
-2.53
524.52
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
944.22
-12.61
41.0
21.0
59.0
111.0
0.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003909 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Polyarginine
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID23177198 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23177198/
RECORD: Rec_0011143 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
Vibrio parahaemolyticus ISP 72-01[0-10% Inhibition = 10 microM]
PMID22319541;24243601;26922474 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22319541/
RECORD: Rec_0032092 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
HIV-1 IIIB
PMID22319541;24243601;26922474 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22319541/
RECORD: Rec_0039089 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 IIIB | MAGI cells
8.861 μM
EC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperKeogan S, Passic S, Krebs FC. | Infection by CXCR4-Tropic Human Immunodeficiency Virus Type 1 Is Inhibited by the Cationic Cell-Penetrating Peptide Derived from HIV-1 Tat. | Int J Pept. 2012;2012:349427. | DOI:10.1155/2012/349427 | PMID:22319541 PMID22319541 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22319541/
RECORD: Rec_0043576 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
Micrococcus luteus ATCC 9341[60-70% Inhibition = 10 microM]
PMID22319541;24243601;26922474 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22319541/
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