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MYP_045425
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Basic Information
Peptide 5
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
40 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
FCYWXXXTKKRPKPFQWFWLXKKLMYPTYLKKFQWAVXHL
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0247532 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bombesin-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Reported in source metadata; exact sites not clearly specified.
Aib = = 1-amino-isobutyric acid, O= Ornithine, Pen=penicillamine, CyLeu=cycloleucine or 1-aminocyclopentane-1-carboxylic acid and disulfide bond between Cys and Pen
Bio-Activity Profile
Anticancer Cytotoxic
KB
0.001 μM
Inhibition
PMID17559067 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17559067/
RECORD: Rec_0275027 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bombesin-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Reported in source metadata; exact sites not clearly specified.
Aib = = 1-amino-isobutyric acid, O= Ornithine, Pen=penicillamine, CyLeu=cycloleucine or 1-aminocyclopentane-1-carboxylic acid and disulfide bond between Cys and Pen
Bio-Activity Profile
Anticancer
MiaPaCa.2
0.001 μM
Inhibition
PMID17559067 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17559067/
RECORD: Rec_0290731 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bombesin-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Reported in source metadata; exact sites not clearly specified.
Aib = = 1-amino-isobutyric acid, O= Ornithine, Pen=penicillamine, CyLeu=cycloleucine or 1-aminocyclopentane-1-carboxylic acid and disulfide bond between Cys and Pen
Bio-Activity Profile
Anticancer
MOLT-4
0.001 μM
Inhibition
PMID17559067 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17559067/
RECORD: Rec_0355459 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bombesin-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Reported in source metadata; exact sites not clearly specified.
Aib = = 1-amino-isobutyric acid, O= Ornithine, Pen=penicillamine, CyLeu=cycloleucine or 1-aminocyclopentane-1-carboxylic acid and disulfide bond between Cys and Pen
Bio-Activity Profile
Anticancer
PTC
>10 μM
ED50
PMID17559067 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17559067/
RECORD: Rec_0355725 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bombesin-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Reported in source metadata; exact sites not clearly specified.
Aib = = 1-amino-isobutyric acid, O= Ornithine, Pen=penicillamine, CyLeu=cycloleucine or 1-aminocyclopentane-1-carboxylic acid and disulfide bond between Cys and Pen
Bio-Activity Profile
Anticancer
MOLT-4
1 μM
Inhibition
PMID17559067 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17559067/
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