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MYP_045404
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Basic Information
Lactocin S
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
37 amino acids
C173H273N43O52S3
Standard
Sequence
STPVLASVAVSMELLPTASVLYSDVAGCFKYSAKHHC
Physicochemical Analysis
3883.47 Da
6.66
-0.39
-0.73
-0.0104
0.58
0.40
0.26
16.08
94.86
0.0811
2980.00
3105.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1479.64
-14.94
54.0
57.0
120.0
271.0
7.0
36.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0128874 VERIFIED: YES
Provenance & Taxonomy
Lactobacillus sakei L45 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Lactobacillus
PaperBacteriocin lactocin-S Evidence URLhttps://www.uniprot.org/uniprotkb/P23826/entry
RECORD: Rec_0144023 VERIFIED: YES
Provenance & Taxonomy
Lactobacillus sakei [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Deamination
Cyclization
Two lanthionines(S32-C37,S23-C28)
Bio-Activity Profile
Antimicrobial Antibacterial
Listeria innocua
PaperPubMed PMID: 1872611 | PubMed PMID: 7961627 PMID1872611;7961627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1872611/
RECORD: Rec_0150679 VERIFIED: YES
Provenance & Taxonomy
Lactobacillus sakei [Bacterium]
Bacteriocin
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Deamination
Cyclization
Two lanthionines(S32-C37,S23-C28)
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus cereus
PaperPubMed PMID: 1872611 | PubMed PMID: 7961627 PMID1872611;7961627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1872611/
RECORD: Rec_0196805 VERIFIED: YES
Provenance & Taxonomy
Lactobacillus sake [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Lactocin S is the first prokaryotic exception to the rule that only L-amino acids are included in ribosomally synthesized peptideS. Three L-serines were found to be D-alanines (J Biol Chem. 1994;269:27183-5). The N-terminal S is blocked since it has been converted to a pyruvamide form. T2 is dehydrated to Dhb. S7, S11, and S19 were converted to D-alanine by an enzyme.Two thioether rings: S23-C28 and S32-C37
Bio-Activity Profile
Antimicrobial
PaperPurification and amino acid sequence of lactocin S, a bacteriocin produced by Lactobacillus sake L45.
RECORD: Rec_0228790 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
None
None
Three L-serine were found to be D-aminoa cid
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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