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MYP_045079
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Basic Information
SARS-CoV S (192-203), SP-4
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Antiviral mechanism ▸ Pseudovirus inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
12 amino acids
C73H102N14O17
Standard
Sequence
GFLYVYKGYQPI
Physicochemical Analysis
1447.67 Da
8.43
0.76
0.55
0.0630
0.13
0.40
0.35
4.78
89.17
0.3333
4470.00
4470.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
504.43
-0.27
17.0
18.0
42.0
104.0
5.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0151760 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 16337697 PMID16337697 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16337697/
RECORD: Rec_0309359 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-COV Pseudovirus inhibition
SARS-CoV | Vero cells
0.0043±0.00218 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperDesign and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction. | Ho TY, Wu SL, Chen JC, Wei YC, Cheng SE, Chang YH, Liu HJ, Hsiang CY. | Antiviral Res. 2006 Feb;69(2):70-6. | DOI:10.1016/j.antiviral.2005.10.005 | PMID:16337697 PMID16337697 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16337697/
RECORD: Rec_0309399 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV:Inhibition of pseudovirus infection in Vero cells
0.0043±0.00218 μM
IC50
PaperPubMed PMID: 16337697 PMID16337697 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16337697/
RECORD: Rec_0315176 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
Synthetic antiviral peptide
694009
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
0.0043 μM
IC50
PaperDesign and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction PMID16337697 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16337697/