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MYP_044998
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Basic Information
Safencin (48-70)[G2,18W,T5K]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
25 amino acids
C153H245N43O33
Standard
Sequence
AWKEKIRQYLKNEIKKKWRKAVIAW
Physicochemical Analysis
3214.85 Da
10.46
6.79
6.59
0.2717
-1.10
0.68
-0.31
11.80
86.00
0.1600
17990.00
17990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1296.04
-4.65
47.0
40.0
113.0
229.0
7.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000911 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic
Human keratinocytes HaCat
10 μM
Cytotoxicity
PMID29463889 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29463889/
RECORD: Rec_0128500 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiparasitic Toxicity
THP-1 cells
<20 μM
CC50
PaperRationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties PMID36342284 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36342284/
RECORD: Rec_0148784 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Streptococcus pyogenes GAS M1T1
8 μM
MIC
PMID29463889 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29463889/
RECORD: Rec_0236130 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
8 μM
PMID29463889 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29463889/
RECORD: Rec_0279431 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas syringae
PMID29463889 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29463889/
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