Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length515 amino acids

Chemical FormulaC2648H4098N652O744S22

DescriptionStandard

        MMCTKMVQVLWGCFLLWNLYISSAQTIYPGIKARATQRALDYGIQAGMEMIEQMVKERNIQDLKGSESPEFLKIYYVNYHFINIKINAFALPNTSLAFVPGVGIRALINHGTANISTDWEIKSPLFQDTGGADLFLSGVYFTGIVVLAQDDFGHPILKLQDCYAQVSHNDISFSGELSVLYNSFAEPMEKPILKNLNKMLCPIITSEVEAVNANLSRLEVLRKIDNYTLLDYSLISSPEITENYIDLNLKGVFYPLENLTDPPFSSVPFVLPEHNDSMIYIGISEYFFKSASYAYFTAGAFNVTLTTEEIFSHLIRNSQGLGNMLSRIAELYILSQPFMVQVLATQPPVVNLLPGNFTLDIPASFVILTQSKNSTAETIVSMDFVASTNVALAILGQRLICSLSLNRFHLSLPESSRSNVEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISFVNSDIEVLEVRIININCPISFHSRICLFLFCLLFVLFCFALFFPSPGNFINKMFSS
    

Molecular Weight57676.21 Da

Isoelectric Point (pI)5.42

Net Charge (pH 7.0)-10.66

Net Charge (pH 7.4) -11.62

Charge Density (pH 7.0) -0.0207

GRAVY Index0.31

Hydrophobic Moment 0.69

Boman Index0.21

Instability Index46.50

Aliphatic Index 107.71

Aromaticity 0.1146

Extinction Coeff. Reduced 43320.00

Extinction Coeff. Oxidized 43820.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0264047 VERIFIED: NO

Provenance & Taxonomy

OrganismPhyseter macrocephalus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria