Peptide Database

Peptide NameHuman islet amyloid polypeptide

Function Ontology

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Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC174H268N48O56S2

DescriptionStandard

        KCNTATCAVQWLANFLVHSSNNFSVSLSLTNVGSNTY
    

Molecular Weight3992.41 Da

Isoelectric Point (pI)8.05

Net Charge (pH 7.0)0.83

Net Charge (pH 7.4) 0.54

Charge Density (pH 7.0) 0.0223

GRAVY Index0.17

Hydrophobic Moment 0.42

Boman Index0.17

Instability Index-0.80

Aliphatic Index 81.62

Aromaticity 0.1081

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1705.57

LogP -23.54

H-bond Donors 61.0

H-bond Acceptors 60.0

Rotatable Bonds 126.0

Heavy Atoms 280.0

Ring Count 6.0

Amide Bonds 43.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0318453 VERIFIED: YES

Provenance & Taxonomy

OrganismRousettus aegyptiacus [Animal]

Structure & Mods

ConfigDNA-encoded linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

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TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)