Peptide Database

Peptide NameSLAY-screened peptide P3474

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC75H117N23O21S2

DescriptionStandard

        LIAHCTNSGNFPKHAM
    

Molecular Weight1741.00 Da

Isoelectric Point (pI)8.24

Net Charge (pH 7.0)0.92

Net Charge (pH 7.4) 0.60

Charge Density (pH 7.0) 0.0577

GRAVY Index-0.11

Hydrophobic Moment 0.31

Boman Index0.14

Instability Index12.39

Aliphatic Index 61.25

Aromaticity 0.0625

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 701.05

LogP -7.95

H-bond Donors 24.0

H-bond Acceptors 26.0

Rotatable Bonds 54.0

Heavy Atoms 121.0

Ring Count 4.0

Amide Bonds 17.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0116070 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/