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MYP_044653
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Basic Information
Polybia-MP1S-D8N
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
14 amino acids
C78H132N20O19
Standard
Sequence
IDWKKLLNAAKQIL
Physicochemical Analysis
1654.01 Da
9.70
1.76
1.55
0.1256
0.06
0.69
0.07
33.86
153.57
0.0714
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
658.95
-2.30
22.0
21.0
58.0
117.0
2.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0353707 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The oct-4-enyl hydrocarbon staple between Leu6 and Ala10
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
0.8 μM
MIC
PMID29075946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29075946/
RECORD: Rec_0366627 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The oct-4-enyl hydrocarbon staple between Leu6 and Ala10
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
50 μM
MIC
PMID29075946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29075946/
RECORD: Rec_0379429 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The oct-4-enyl hydrocarbon staple between Leu6 and Ala10
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID29075946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29075946/
RECORD: Rec_0398725 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Polybia-MP1
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 6 and 10) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (6) and Ⓧ (10) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Shigella dysenteriae
100 μg/mL
MIC
PaperHuy X Luong, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim. Antimicrobial activity and stability of stapled helices of polybia-MP1. Arch Pharm Res. 2017 Dec;40(12):1414-1419. Epub 2017 Oct 26. PMID29075946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29075946/
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