Peptide Database

Peptide NameSLAY-screened peptide P1723

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC122H194N34O30S

DescriptionStandard

        TTAFICILRRYRRDAYQIYLL
    

Molecular Weight2649.12 Da

Isoelectric Point (pI)9.78

Net Charge (pH 7.0)2.39

Net Charge (pH 7.4) 2.18

Charge Density (pH 7.0) 0.1136

GRAVY Index0.17

Hydrophobic Moment 0.76

Boman Index-0.05

Instability Index70.78

Aliphatic Index 120.95

Aromaticity 0.1905

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1074.46

LogP -6.02

H-bond Donors 42.0

H-bond Acceptors 34.0

Rotatable Bonds 85.0

Heavy Atoms 187.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0014907 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/