Peptide Database

Peptide NameGambicin

Function Ontology

Antimicrobial

Antiparasitic ▸ Antimalarial

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Standard StatusStandard

Sequence Length61 amino acids

Chemical FormulaC288H445N83O89S9

DescriptionStandard

        MVFAYAPTCARCKSIGARYCGYGYLNRKGVSCDGQTTINSCEDCKRKFGRCSDGFITECEF
    

Molecular Weight6782.70 Da

Isoelectric Point (pI)8.46

Net Charge (pH 7.0)2.42

Net Charge (pH 7.4) 2.07

Charge Density (pH 7.0) 0.0398

GRAVY Index-0.31

Hydrophobic Moment 0.73

Boman Index-0.08

Instability Index41.39

Aliphatic Index 41.64

Aromaticity 0.1311

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 6460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2809.94

LogP -33.70

H-bond Donors 109.0

H-bond Acceptors 101.0

Rotatable Bonds 223.0

Heavy Atoms 469.0

Ring Count 9.0

Amide Bonds 63.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0244622 VERIFIED: YES

Provenance & Taxonomy

OrganismAnopheles gambiae [Animal]

FamilyInsect antimicrobial peptide

Tax ID7165

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiparasitic Antimalarial

TargetPlasmodium berghei

Activity10 μM

MethodPercent inhibition; Microscopy (calcein AM and ethidium homodimer staining)

RECORD: Rec_0389050 VERIFIED: YES