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MYP_044469
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Basic Information
Bombinin H-BO1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C76H136N18O18
Standard
Sequence
IIGPVLGLVGKALGGLL
Physicochemical Analysis
1590.00 Da
8.75
0.76
0.55
0.0447
1.81
0.40
0.70
18.01
200.59
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
546.15
-1.40
18.0
19.0
52.0
112.0
1.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016995 VERIFIED: YES
Provenance & Taxonomy
Oriental fire-bellied toad [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antifungal Anticancer
Candida albicans
160 μM
MIC
PaperMolecular characterization and bioactivity evaluation of two novel bombinin peptides from the skin secretion of Oriental fire-bellied toad, Bombina orientalis
RECORD: Rec_0017508 VERIFIED: YES
Provenance & Taxonomy
Bombina orientalis [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
161.1 μM
MIC
PMID29098406 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29098406/
RECORD: Rec_0033701 VERIFIED: YES
Provenance & Taxonomy
skin secretion of Oriental fire-bellied toad,Bombina orientalis [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
of the red cells at a concentration of 40
03 %
Hemolysis
PaperPubMed PMID: 29098406 PMID29098406 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29098406/
RECORD: Rec_0107440 VERIFIED: YES
Provenance & Taxonomy
skin secretion of Oriental fire-bellied toad,Bombina orientalis [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human Red cells: caused 42
PaperPubMed PMID: 29098406 PMID29098406 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29098406/
RECORD: Rec_0120287 VERIFIED: YES
Provenance & Taxonomy
skin secretion of Oriental fire-bellied toad,Bombina orientalis [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Huh-7
8.42 μM
IC50
PaperPubMed PMID: 29098406 PMID29098406 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29098406/
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