Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length123 amino acids

Chemical FormulaC610H1014N168O159S7

DescriptionStandard

        KHCGRGTLKMFLCCWLVLGALIPATLSINPGVKVRLTEKGIEYGKVCVKAQKLNSIQIPDFSGKKKVSPIGKVQYNLSNIRVLKVGIPKSSVDLVPGTGVRMSIGDAFISLNGNWRVKYLRIM
    

Molecular Weight13470.06 Da

Isoelectric Point (pI)10.17

Net Charge (pH 7.0)14.80

Net Charge (pH 7.4) 14.46

Charge Density (pH 7.0) 0.1203

GRAVY Index0.17

Hydrophobic Moment 0.63

Boman Index0.10

Instability Index15.05

Aliphatic Index 110.00

Aromaticity 0.0650

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15720.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5254.71

LogP -44.49

H-bond Donors 187.0

H-bond Acceptors 182.0

Rotatable Bonds 457.0

Heavy Atoms 944.0

Ring Count 17.0

Amide Bonds 131.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0306036 VERIFIED: NO

Provenance & Taxonomy

OrganismNeolamprologus brichardi [Bacterium]

FamilyBPI

Tax ID32507

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence