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MYP_044241
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Basic Information
NP-06
Antimicrobial
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antimicrobial ▸ Quorum sensing modulation
Antiviral
Antiviral ▸ Anti-HIV
Enzyme modulation ▸ Enzyme inhibition ▸ Protein kinase inhibitor
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Regulatory peptide ▸ Cell-cell communication
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
21 amino acids
C97H137N23O27S4
Standard
Sequence
CLGVGSCNDFAGCGYAIVCFW
Physicochemical Analysis
2185.52 Da
4.05
-1.28
-1.54
-0.0609
1.16
0.30
0.50
29.78
74.29
0.1905
6990.00
7240.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
781.96
-6.72
31.0
30.0
64.0
151.0
5.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0191555 VERIFIED: YES
Provenance & Taxonomy
Streptomyces strain [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
PaperNP-06: a novel anti-human immunodeficiency virus polypeptide produced by a Streptomyces species.
RECORD: Rec_0203988 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 19.0%, E 9.5%, T 33.3%, C 38.1% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0286714 VERIFIED: YES
Provenance & Taxonomy
Streptomyces strain AA6532 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1LAI
2.8 μM
IC50
PMID8619594 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8619594/
RECORD: Rec_0289688 VERIFIED: YES
Provenance & Taxonomy
Bacteria [Bacterium]
2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID8689231 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8689231/
RECORD: Rec_0353748 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nodosus [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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