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MYP_044214
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Basic Information
Parigidin-br1
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
32 amino acids
C140H219N35O45S6
Standard
Sequence
GGSVPCGESCVFIPCITSLAGCSCKNKVCYYD
Physicochemical Analysis
3304.83 Da
6.15
-0.30
-0.60
-0.0093
0.48
0.32
0.22
51.63
66.88
0.0938
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1259.18
-15.37
49.0
51.0
102.0
226.0
5.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0192032 VERIFIED: YES
Provenance & Taxonomy
Palicourea rigida [Plant]
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
6-22; 10-24; 15-29
Bio-Activity Profile
Toxin
Staphylococcus aureus strain ATCC 25923
PMID22074926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22074926/
RECORD: Rec_0214773 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Toxic Antimicrobial Cytotoxic Insecticidal
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0254443 VERIFIED: YES
Provenance & Taxonomy
Palicourea rigida [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Insecticidal
Lepidoptera (Diatraea saccharalis)
PMID22074926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22074926/
RECORD: Rec_0301068 VERIFIED: YES
Provenance & Taxonomy
Palicourea rigida [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0366207 VERIFIED: YES
Provenance & Taxonomy
Palicourea rigida [Plant]
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
6-22; 10-24; 15-29
Bio-Activity Profile
Toxin Cytotoxic
It exhibited cytotoxic effects on SF-9 cells with CC50 values to be 1
PMID22074926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22074926/
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