Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length399 amino acids

Chemical FormulaC1945H3108N494O557S18

DescriptionStandard

        MCFPFSFRLAFSQSQTHMLLHAWLLLVALTTLTSGLNPGVKVKLTQKGLEYELGIASIQQKLKTIKLPDVSGSQKVNPIGKVSYSFTNMHIINVGLPQSAVSLVPGAGIKLSIGNAYLSLNGNWRVKYLKFIKDSGSFDLSVSGLSITTTVAVNSDETGRPTVTGNNCVASVGSVTIKFHACCLLCKLYLHLSHFQKPSAVLAKVDEYAEIQYSLVSSPVISTTSVDLSLKGEFYNVGKHQEPPFIPNVFSMPPESNNMLYLGLSSYTANSAGFVYTTAGALSLYITDDMIPASSPIRLNTQTFGAFIPQIAKRFPGLMMKLLVKAAKSPVITFESSNATITATATVTAYAIQVNGTLSPLFVLNMLQIMKVSARSFIKKGLVTVAGSDAPLLCCRITC
    

Molecular Weight42901.63 Da

Isoelectric Point (pI)9.38

Net Charge (pH 7.0)14.03

Net Charge (pH 7.4) 13.26

Charge Density (pH 7.0) 0.0352

GRAVY Index0.32

Hydrophobic Moment 0.60

Boman Index0.20

Instability Index28.52

Aliphatic Index 101.88

Aromaticity 0.0852

Extinction Coeff. Reduced 30370.00

Extinction Coeff. Oxidized 30870.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0335185 VERIFIED: NO

Provenance & Taxonomy

OrganismPeriophthalmus magnuspinnatus [Bacterium]

FamilyBPI

Tax ID409849

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence