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MYP_044170
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Basic Information
H2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Standard
14 amino acids
C69H109N23O18
Standard
Sequence
ASHLGHHALDHLLK
Physicochemical Analysis
1548.75 Da
7.14
0.14
-0.25
0.0103
-0.19
0.50
0.13
3.22
125.71
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
639.89
-4.98
22.0
22.0
50.0
110.0
4.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0163148 VERIFIED: YES
Provenance & Taxonomy
Holothuria tubulosa [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Listeria monocytogenes ATCC 19115 [Mueller –Hinton Broth (MHB) medium]
PMID30857142 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30857142/
RECORD: Rec_0170124 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 71.4%, C 28.6% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperBaAMPs: the database of biofilm-active antimicrobial peptides PMID25760404 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25760404/
RECORD: Rec_0170538 VERIFIED: YES
Provenance & Taxonomy
Holothuria tubulosa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Staphylococcus epidermidis ATCC 35984
0.969 μM
Safranin staining
RECORD: Rec_0232306 VERIFIED: YES
Provenance & Taxonomy
Holothuria tubulosa [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Listeria monocytogenes 89 [Mueller –Hinton Broth (MHB) medium]
5000 μg/mL
MIC
PMID30857142 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30857142/
RECORD: Rec_0258601 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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