Peptide Database

Peptide NamePotassium channel toxin ImKTx88

Function Ontology

Membrane / Ion-channel modulation ▸ Ion channel modulation

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC179H284N54O59S6

DescriptionStandard

        QIYTSKECNGSSECYSHCEGITGKRSGKCINKKCYCYR
    

Molecular Weight4328.89 Da

Isoelectric Point (pI)8.84

Net Charge (pH 7.0)3.79

Net Charge (pH 7.4) 3.43

Charge Density (pH 7.0) 0.0997

GRAVY Index-0.96

Hydrophobic Moment 0.68

Boman Index-0.26

Instability Index49.80

Aliphatic Index 30.79

Aromaticity 0.1053

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 6335.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1886.30

LogP -25.16

H-bond Donors 74.0

H-bond Acceptors 70.0

Rotatable Bonds 148.0

Heavy Atoms 298.0

Ring Count 5.0

Amide Bonds 40.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0204984 VERIFIED: YES

Provenance & Taxonomy

OrganismIsometrus maculatus [Animal]

Structure & Mods

Configlinear disulfide-stabilized peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide8-30, 14-34, 18-36

Bio-Activity Profile

Function

Toxin Ion Channel Blocker Potassium Channel Blocker

TargetKv1.3/KCNA3

Activity0.000091 μM

MethodIC50