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MYP_043980
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Basic Information
cliotide T8
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C130H210N34O41S6
Standard
Sequence
GIPCGESCVFIPCISSVVGCSCKSKVCYNN
Physicochemical Analysis
3097.65 Da
7.77
0.70
0.40
0.0233
0.67
0.35
0.24
23.78
77.67
0.0667
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1186.54
-15.27
46.0
48.0
97.0
211.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011751 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Cytotoxic Anti-Gram-negative
Escherichia coli
PaperDiscovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family PMID21596752 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21596752/
RECORD: Rec_0087467 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Cytotoxic
HeLa cells
PaperDiscovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family PMID21596752 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21596752/
RECORD: Rec_0143376 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0277136 VERIFIED: NO
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
Structure & Mods
backbone-cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial