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MYP_043927
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Basic Information
hCGRP(Human Calcitonin gene-related peptide)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Vasoactive neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
37 amino acids
C163H268N50O50S2
Standard
Sequence
ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF
Physicochemical Analysis
3792.31 Da
9.50
2.86
2.59
0.0774
0.21
0.59
0.10
32.84
81.62
0.0541
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1614.83
-21.92
59.0
56.0
122.0
265.0
4.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014010 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Calcitonin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
2-7
Bio-Activity Profile
Vasodilator
Radioimmunoassay, RP-HPLC
Merino-Corriedale cross ewes (sheep) plasma, in vivo; 216 s
PMID3261772 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3261772/
RECORD: Rec_0065441 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0114892 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Calcitonin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
2-7
Bio-Activity Profile
Hormone Calcium-regulatory peptide
PMID6609312 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6609312/
RECORD: Rec_0139333 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Calcitonin gene-related peptide
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
2-7
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasodilator Cardiovascular Growth regulation Development regulation Receptor modulation
Experimental: 6.9±0.9 (first phase) minute; /414 seconds; Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Calcitonin gene-related peptide 1 (Homo sapiens): PMID 6609312##3922013 PMID6609312;3922013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6609312/
RECORD: Rec_0152053 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans NCTC 3179
63 μg/mL
MIC
PaperAntimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites.
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