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MYP_043901
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Basic Information
O-15 (Oncocin)
Antimicrobial
Antimicrobial ▸ Antibacterial
not Standard
19 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
VDKPPYLPRPRPPRXIYNR
Physicochemical Analysis
0.00 Da
0.00
0.00
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0115352 VERIFIED: YES
Provenance & Taxonomy
Oncopeltus [Animal]
Oncocin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
Orn=Ornithine
Bio-Activity Profile
Antimicrobial
4 μg/mL
MIC
Full mouse serum, in vivo; 6120 s
PaperBactericidal oncocin derivatives with superior serum stabilities PMID21185160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185160/
RECORD: Rec_0133551 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Propylamidation
Orn=Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli BL21AI
4 μg/mL
MIC
Mouse serum: The half-life is 102 ±2 min in full mouse serum
PaperKnappe D, Kabankov N, Hoffmann R Bactericidal oncocin derivatives with superior serum stabilities Int J Antimicrob Agents. 2011 Feb;37(2):166-70. PMID:21185160 https://pubmed.ncbi.nlm.nih.gov/21185160/ PMID21185160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185160/
RECORD: Rec_0144394 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
orn =Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli BL21AI
8 μg/mL
MIC
Mouse serum: The half-life is 90 min in 25% aqueous mouse serum
PaperKnappe D, Kabankov N, Hoffmann R Bactericidal oncocin derivatives with superior serum stabilities Int J Antimicrob Agents. 2011 Feb;37(2):166-70. PMID:21185160 https://pubmed.ncbi.nlm.nih.gov/21185160/ PMID21185160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185160/
RECORD: Rec_0181049 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 15
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli BL21AI
4 μg/mL
MIC
PMID21185160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185160/
RECORD: Rec_0217480 VERIFIED: YES
Provenance & Taxonomy
Oncopeltus [Animal]
Oncocin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
orn =Ornithine
Bio-Activity Profile
Antimicrobial
8 μg/mL
MIC
25% mouse serum, in vivo; 5400 s
PaperBactericidal oncocin derivatives with superior serum stabilities PMID21185160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185160/
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