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MYP_043901
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Basic Information
O-15 (Oncocin)
Antimicrobial
Antimicrobial ▸ Antibacterial
not Standard
19 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
VDKPPYLPRPRPPRXIYNR
Physicochemical Analysis
0.00 Da
0.00
0.00
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000344 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Beta-Hr =β-homoarginine
Bio-Activity Profile
Antimicrobial Antibacterial
Micrococcus luteus ATCC 10240
16 μg/mL
MIC
Mouse serum: The half-life is 150 min in 25% aqueous mouse serum
PaperKnappe D, Kabankov N, Hoffmann R Bactericidal oncocin derivatives with superior serum stabilities Int J Antimicrob Agents. 2011 Feb;37(2):166-70. PMID:21185160 https://pubmed.ncbi.nlm.nih.gov/21185160/ PMID21185160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185160/
RECORD: Rec_0048413 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 15
Bio-Activity Profile
Antimicrobial Antibacterial
Micrococcus luteus ATCC 10240
16 μg/mL
MIC
PMID21185160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185160/
RECORD: Rec_0055575 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Propylamidation
Orn=Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella pneumoniae DSM 681
4 μg/mL
MIC
Mouse serum: The half-life is 102 ±2 min in full mouse serum
PaperKnappe D, Kabankov N, Hoffmann R Bactericidal oncocin derivatives with superior serum stabilities Int J Antimicrob Agents. 2011 Feb;37(2):166-70. PMID:21185160 https://pubmed.ncbi.nlm.nih.gov/21185160/ PMID21185160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185160/
RECORD: Rec_0074035 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
orn =Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial
Micrococcus luteus ATCC 10240
16 μg/mL
MIC
Mouse serum: The half-life is 90 min in 25% aqueous mouse serum
PaperKnappe D, Kabankov N, Hoffmann R Bactericidal oncocin derivatives with superior serum stabilities Int J Antimicrob Agents. 2011 Feb;37(2):166-70. PMID:21185160 https://pubmed.ncbi.nlm.nih.gov/21185160/ PMID21185160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185160/
RECORD: Rec_0087017 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 15
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli BL21AI
8 μg/mL
MIC
PMID21185160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185160/
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