Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length485 amino acids

Chemical FormulaC2442H3904N630O681S15

DescriptionStandard

        TKMARGPDDTWRWATLVVLAALGTAVTATTSPGIVARITQKGLDYACQQGVATLQKELEKVTIPTFSGSFKMKYLGKGKYTFYSLVIREFKLPNSQIRPLPGQDLDLSIKDASIKMSGKWKARKNFIKVSGNFDLSVEGISILAGLKLGYDPTSGHPTVTCSSCSSHINSVRVRISRSSLGWLIQLFRKKIESSLRNSMNRKICKVVTSTVSSKLQPYFQTLPVTTKIDNVAGIDYSLVAPPKATADNLDVLLKGEFFRLAHRGPPPFAPPALTLPNDHNRMVYLGISEYLFNTAGLVYQEAGVLHFTLSDDTLPKESKFLLTTKSFGTLLPQVAKMFPDMKMQLLIWASSPPNIAVCPTGLHLTFALDTQAVAVLPDSSLAPLFLLEMYVNVSVDIGTRSDRLVGELKLDKLLLELKHSDIGPFPVELLQTIMNYVVPTVVIPKINKKLQKGFPLPLPASIQLFNLVLQPHQDFLLFGADVRYS
    

Molecular Weight53465.91 Da

Isoelectric Point (pI)9.52

Net Charge (pH 7.0)17.06

Net Charge (pH 7.4) 16.28

Charge Density (pH 7.0) 0.0352

GRAVY Index0.07

Hydrophobic Moment 0.74

Boman Index0.11

Instability Index36.70

Aliphatic Index 102.29

Aromaticity 0.0845

Extinction Coeff. Reduced 46870.00

Extinction Coeff. Oxidized 47120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0359581 VERIFIED: NO

Provenance & Taxonomy

OrganismMonodon monoceros [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence