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MYP_043799
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Basic Information
SC29EK
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
29 amino acids
C168H266N42O54
Standard
Sequence
WEEWDKKIEEYTKKIEELIKKSEEQQKKN
Physicochemical Analysis
3738.16 Da
5.33
-1.23
-1.46
-0.0423
-2.09
0.69
-0.50
85.03
53.79
0.1034
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1643.52
-11.24
55.0
53.0
139.0
264.0
5.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0218664 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 HXB2:inhibition of cell-cell fusion in TZM-bl cells
0.001±0.0002 μM
IC50
PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/
RECORD: Rec_0342009 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3 D36G/V38A
PMID19114674;31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114674/
RECORD: Rec_0353224 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3 D36G/N43D/S138A
PMID19114674;31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114674/
RECORD: Rec_0375604 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3 D36G/N43D
PMID19114674;31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114674/
RECORD: Rec_0382594 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 NL4-3:inhibition of pseudovirus entry in TZM-bl cells
0.0012±0.0002 μM
IC50
PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/
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