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MYP_043718
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Basic Information
Melectin (MEP; Insects, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C96H166N24O20S2
Standard
Sequence
GFLSILKKVLPKVMAHMK
Physicochemical Analysis
2040.62 Da
10.48
3.84
3.58
0.2135
0.62
0.57
0.21
18.83
124.44
0.0556
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
702.22
-1.48
24.0
27.0
71.0
142.0
3.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0258979 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
MEP
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical or residue-modified peptide [Modified]
None
Amidation
The J (position: 14) in sequence indicates norleucine. The Ⓧ (position: 13 and 17) indicates 2-(4'-pentenyl) alanine in the S configuration. Ⓧ (13) and Ⓧ (17) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
10.8 μM
MIC
PaperHubert Chapuis, Jiřina Slaninová, Lucie Bednárová, Lenka Monincová, Miloš Buděšínský, Václav Čeřovský. Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera. Amino Acids. 2012 Nov;43(5):2047-58. Epub 2012 Apr 28. PMID22526241 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22526241/
RECORD: Rec_0259552 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
MEP
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical or residue-modified peptide [Modified]
None
Amidation
The J (position: 14 and 17) in sequence indicates norleucine. The Ⓧ (position: 5 and 9) indicates 2-(4'-pentenyl) alanine in the S configuration. Ⓧ (5) and Ⓧ (9) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial Antibacterial
Micrococcus luteus
1.5 μM
MIC
PaperHubert Chapuis, Jiřina Slaninová, Lucie Bednárová, Lenka Monincová, Miloš Buděšínský, Václav Čeřovský. Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera. Amino Acids. 2012 Nov;43(5):2047-58. Epub 2012 Apr 29. PMID22526241 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22526241/
RECORD: Rec_0266730 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Rat erythrocytes
100 μM
LC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/20499256/ PMID20499256 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20499256/
RECORD: Rec_0273284 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
MEP
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical or residue-modified peptide [Modified]
None
Amidation
The J (position: 14) in sequence indicates norleucine. Ⓧ (position: 5, 9, 13 and 17) are 2-(4'-pentenyl) alanine in the S configuration. Ⓧ (5) and Ⓧ (9), Ⓧ (13) and Ⓧ (17) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
46.7 μM
MIC
PaperHubert Chapuis, Jiřina Slaninová, Lucie Bednárová, Lenka Monincová, Miloš Buděšínský, Václav Čeřovský. Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera. Amino Acids. 2012 Nov;43(5):2047-58. Epub 2012 Apr 30. PMID22526241 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22526241/
RECORD: Rec_0275076 VERIFIED: YES
Provenance & Taxonomy
Melecta albifrons [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
6.8 μM
MIC
PMID18942691 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18942691/
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