‹ ›
MYP_043686
← PREVIOUS NEXT → BACK
Basic Information
HD5[T7R]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
32 amino acids
C146H249N53O44S6
Standard
Sequence
ATCYCRRGRCATRESLSGVCEISGRLYRLCCR
Physicochemical Analysis
3643.26 Da
9.22
4.74
4.46
0.1481
-0.23
0.69
-0.29
31.69
64.06
0.0625
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1614.93
-21.01
69.0
55.0
121.0
249.0
2.0
31.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0036083 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/
RECORD: Rec_0047647 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Sequence-variant derivative
Bio-Activity Profile
Antiviral Entry inhibitor
Herpes simplex virus 2 (Virus entry); CaSki
10.979142 μM
Plaque assay
PaperEnhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites. | Wang A, Chen F, Wang Y, Shen M, Xu Y, Hu J, Wang S, Geng F, Wang C, Ran X, Su Y, Cheng T, Wang J. | J Virol. 2013 | PMID:23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/
RECORD: Rec_0109697 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30.
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
Herpes simplex virus2 (HSV-2)
10.98 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperEnhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites. | Wang A, Chen F, Wang Y, Shen M, Xu Y, Hu J, Wang S, Geng F, Wang C, Ran X, Su Y, Cheng T, Wang J. | J Virol. 2013 Mar;87(5):2835-45. | DOI:10.1128/JVI.02209-12 | PMID:23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/
RECORD: Rec_0242030 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/
RECORD: Rec_0274290 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Bio-Activity Profile
Antimicrobial Antiviral
Herpes simplex virus2(HSV-2):neutralization activity against HSV-2 during the preinfection stage
40 μg/mL
IC50
PaperPubMed PMID: 23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/
1 2 NEXT LAST
Showing 5 records on this page · Page 1 of 2