Peptide Database

Peptide NameMT-SC25EK

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length27 amino acids

Chemical FormulaC156H244N36O51S

DescriptionStandard

        MTWEEWDKKIEEYTKKIEELIKKSEEQ
    

Molecular Weight3471.88 Da

Isoelectric Point (pI)4.73

Net Charge (pH 7.0)-3.48

Net Charge (pH 7.4) -3.72

Charge Density (pH 7.0) -0.1290

GRAVY Index-1.65

Hydrophobic Moment 0.69

Boman Index-0.34

Instability Index76.82

Aliphatic Index 57.78

Aromaticity 0.1111

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1467.33

LogP -8.48

H-bond Donors 50.0

H-bond Acceptors 49.0

Rotatable Bonds 126.0

Heavy Atoms 244.0

Ring Count 5.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0193528 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1 NL4-3:inhibition of pseudovirus entry in TZM-bl cells

Activity0.0019±0.0002 μM

MethodIC50

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. Viruses. 2019 Jul 3;11(7):609. doi: 10.3390/v11070609. PMID: 31277353. PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

RECORD: Rec_0365041 VERIFIED: YES