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MYP_043554
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Basic Information
Brevinin-1SPd
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
20 amino acids
C99H165N23O22S3
Standard
Sequence
FFPIIAGMAAKVICAITKKC
Physicochemical Analysis
2125.70 Da
9.39
2.74
2.50
0.1369
1.38
0.52
0.44
21.05
112.50
0.1000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
705.72
-2.47
26.0
28.0
69.0
147.0
3.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0373925 VERIFIED: NO
Provenance & Taxonomy
American frog [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
14-20
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0380512 VERIFIED: YES
Provenance & Taxonomy
Lithobates septentrionalis [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
14-20
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
13.0 μM
MIC
PaperC.R. Bevier et al. / Comparative Biochemistry and Physiology, Part C 139 (2004) 31-38. Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis)
RECORD: Rec_0384114 VERIFIED: YES
Provenance & Taxonomy
Rana septentrionalis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID15556063 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15556063/
RECORD: Rec_0420671 VERIFIED: YES
Provenance & Taxonomy
Lithobates septentrionalis [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
14-20
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
8.0 μM
HC50
PaperC.R. Bevier et al. / Comparative Biochemistry and Physiology, Part C 139 (2004) 31-38. Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis)
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