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MYP_043554
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Basic Information
Brevinin-1SPd
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
20 amino acids
C99H165N23O22S3
Standard
Sequence
FFPIIAGMAAKVICAITKKC
Physicochemical Analysis
2125.70 Da
9.39
2.74
2.50
0.1369
1.38
0.52
0.44
21.05
112.50
0.1000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
705.72
-2.47
26.0
28.0
69.0
147.0
3.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0319064 VERIFIED: YES
Provenance & Taxonomy
Rana septentrionalis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
14-20
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus
3 μM
MIC
PaperPurification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis).
RECORD: Rec_0333628 VERIFIED: YES
Provenance & Taxonomy
Lithobates septentrionalis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic
Candida albicans
PMID15556063 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15556063/
RECORD: Rec_0339271 VERIFIED: YES
Provenance & Taxonomy
Lithobates septentrionalis [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
14-20
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
3.0 μM
MIC
PaperC.R. Bevier et al. / Comparative Biochemistry and Physiology, Part C 139 (2004) 31-38. Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis)
RECORD: Rec_0359084 VERIFIED: YES
Provenance & Taxonomy
Rana septentrionalis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
human erythrocytes
8 μM
HC50
PMID15556063 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15556063/
RECORD: Rec_0363344 VERIFIED: YES
Provenance & Taxonomy
Rana septentrionalis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
13 μM
MIC
PMID15556063 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15556063/
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